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Muscle abnormalities worsen after post-exertional malaise in long COVID
Appelman B, Charlton BT, Goulding RP, et al. · Nature Communications · 2024
Patients' muscle differed from that of recovered, more active controls at baseline, but the claim that abnormalities worsen after post-exertional malaise is mostly unsupported: most changes were shared with controls or never tested between groups.
Muscle damage claims lack the between-group testTissue scoring yes/no, blinding to time point unclearControls did the same exercise test and biopsies